Uveal
melanoma is the most common tumor of the adult eye, particularly in developing
countries. Skin cancer, skin, has been
extensively studied, little is known about the molecular causes of cancer
uveal. It has been shown to activate
BRAF mutations lead to activation of ERK platform (as defined in the
extracellular signal kinase) were found in many of the main active ingredient
in mainstream tumors.1 ERK1 / 2 skin cancer cells,
choroidal tumor, the expression of the Royal Air Force WTB 0.2 WTRas our
program for four plays the same role in cell growth and converts the signal
from path B cell lines of uveal melanoma and the timely
delivery of WTB-Raf and the rare human uveal melanoma cell performance
-Raf/MEK/ERK strains B-Musharraf 's (V600EB Royal Air Force UK) 0.5 V600E
mutation, it also revealed that siRNA-mediated B-RAF to
eliminate or BAY43-9006 inhibition of the British Royal Air Force B-2 inhibit
activation / ERK1 to reduce significantly the expression of cyclin D1, and near
Raf and Royal Air Force WTB uveal
melanoma cells V600EB lines.5 cancel these results highlight the path of
B-Raf/ERK1 / 2 points the role of cell proliferation of cells, and
transformation. Uveal melanoma expressed in
cells of Musharraf WTB lines.6 7 B-Raf activation of this signaling pathway
activation, even if it is a milestone in the development of skin cancer and
stimulate the development of B cells , and convert it to the ring
supervisor autocrine growth factor, is not sufficient to cause malignant
tumors, and other traces, which refers to all the needs of growth factor in the
uvea cell lines Melanoma caused by the wheel
of cancer state.8 activation of ERK1 / 2 depends on the details of SCF
activation of c-kit 0.7 supercritical fluid, may also be interested in the
activation of phosphoinositide 3 - kinase (PI3K) tumor . The role of PI3K signs of
uveal melanoma is poorly understood.Surprisingly, the PI3K
inhibitor LY294002 almost completely inhibited the cell to cope with Chi Mei
-1, the royal cell V600EB activate the power of uveal melanoma cells spread to
the formation of a finger and reliable studies B-Raf / ERK showed that the B - the
need for activation of Raf proliferation.9, but can be connected to cell
proliferation is the full path and PI3K
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